Psychotropic agents. II. Synthesis and psychotropic activity of conformationally restricted butyrophenone analogs.

Conformationally Restricted Fentanyl Analogs

Synthesis, analgesic activity and preliminary molecular modeling studies of the cisand trans-fused octahydro-l,2,3,4,4a,5,11,1 la-pyrido[3,4-c][1,5]benzoxazepines 8 and 9, the first rigid fentanyl analogs with a conformationally restricted 4-anilido group that retain antinociceptive properties, are reported. Fentanyl (1) is the prototype of the highly potent 4-anilidopiperidine class of synthet...

Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.

A chiral synthesis of a series of hexahydroisobenzofuran (HIBF) nucleosides has been accomplished via glycosylation of a stereo-defined (syn-isomer) sugar motif 16 with the appropriate silylated bases. All nucleoside analogs were obtained in 52-71% yield as a mixture of alpha- and beta-anomeric products increasing the breadth of the novel nucleosides available for screening. The structure of th...

Treatment of dyspnea with psychotropic agents.

Anesthetic concerns for patients on psychotropic agents

The incidence and prevalence of mental illness is expected to increase substantially in the next twenty years. There are two reasons for this increase: (1) the declining mortality rate of mentally ill individuals and (2) the increasing life span of persons with chronic illnesses and disabilities that are associated with psychological problems.' Many of these people are now seen in the operating...

Effects of Different Psychotropic Agents on the Central Nerve Growth Factor Protein

Objective(s) Psychotropic medications produce their effects, in part, through increasing neurotrophin levels in the brain. Since studies concerning nerve growth factor (NGF) analysis have been limited in scope, in the current experiments we investigated the effects of diverse psychotropic agents on NGF protein levels in various brain regions of rat. Materials and Methods Male Wistar rats rec...